Lack of Vitamin D Linked to Alzheimer’s and Vascular Dementia

Researchers have found that low serum levels of vitamin D are associated with an increased risk for host of health problems ranging from diabetes and osteoporosis to depression, dental cavities and periodontal disease. What’s more, in 2008, numerous studies concluded that people with higher serum levels of vitamin D had a greatly reduced risk of cardiovascular disease as well as a lowered chance of death due to cardiac causes. Curiously, all of these seemingly separate conditions are either known risk factors for dementia or tend to strike before dementia is diagnosed. Now scientist William B. Grant, PhD, of the Sunlight, Nutrition, and Health Research Center (SUNARC) has put these facts together and has come up with a startling new hypothesis about the cause of mind-robbing Alzheimer’s disease and other vascular dementias: vitamin D deficiency.

His article in the current issue of the Journal of Alzheimer’s Disease (May 2009) explains why further investigation is needed to identify any causative linkages between vitamin D and dementia, including the type known as Alzheimer’s disease. As an example of how risk factors for the development of Alzheimer’s disease and vascular dementia could be directly related to vitamin D deficiencies, Dr. Grant cites several studies that have correlated tooth loss with the development of cognitive impairment and Alzheimer’s or vascular dementia. Why do people lose teeth? Primarily, he points out in his article, tooth loss is the result of dental caries and/or periodontal disease — and both those conditions are linked to low levels of vitamin D.

In addition, Dr. Grant’s article explains that ample biological evidence has accumulated showing how critical vitamin D is to healthy brain development and function. In fact, vitamin D in sufficient amounts seems to protect brain cells and reduce inflammation. A lack of vitamin D has been associated with increased inflammation and a pro-inflammatory state has been linked, in turn, with dementia.

Dr. Grant is calling for studies of levels of vitamin D in people before dementia is diagnosed and research to determine if vitamin D supplementation is warranted to potentially prevent dementia. In addition, because elderly people are frequently deficient in vitamin D, he suggests that those over 60 years old should consider having their serum vitamin D level tested and, if their vitamin D status is low, he recommends taking 1000 to 2000 IU a day of vitamin D3 supplements and/or increasing the time they spend in the sun year round.

“There are established criteria for causality in a biological system. The important criteria include strength of association, consistency of findings, determination of the dose-response relation, an understanding of the mechanisms, and experimental verification,” Dr. Grant states in the Journal of Alzheimer’s Disease article. “To date, the evidence includes observational studies supporting a beneficial role of vitamin D in reducing the risk of diseases linked to dementia such as vascular and metabolic diseases, as well as an understanding of the role of vitamin D in reducing the risk of several mechanisms that lead to dementia.”

Finding out how vitamin D might be able to help prevent and perhaps treat Alzheimer’s and other dementias can’t come a moment too soon. The Alzheimer’s Association recently reported that 5.3 million Americans currently have Alzheimer’s disease. It is the seventh-leading cause of death in the U.S.

Reference: “Does Vitamin D Reduce the Risk of Dementia?” by William B. Grant, Ph.D. , Journal of Alzheimer’s Disease, 17:1 (May 2009).

For more information:http://www.sunarc.org/http://www.alz.org/alzheimers_disease_facts_figures.asp

About the author
Sherry Baker is a widely published writer whose work has appeared in Newsweek, Health, the Atlanta Journal and Constitution, Yoga Journal, Optometry, Atlanta, Arthritis Today, Natural Healing Newsletter, OMNI, UCLA’s “Healthy Years” newsletter, Mount Sinai School of Medicine’s “Focus on Health Aging” newsletter, the Cleveland Clinic’s “Men’s Health Advisor” newsletter and many others.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: